Significant drug–drug interaction between warfarin and nafcillin
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چکیده
منابع مشابه
Interaction between warfarin and sulphamethoxazole.
A patient is described in whom there was strong circumstantial evidence of an interaction between warfarin and co-trimaxazole. To test the validity of this hypothesis a series of in vitro and in vivo human studies were untaken. The results indicate that interaction may occur in which the sulphamethoxazole moiety of co-trimoxazole displaces warfarin from its binding sites on plasma albumin. Neve...
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AIMS Nafcillin (Wyeth Laboratories, Philadelphia, PA, USA) has been reported to induce the metabolism of cyclosporin and warfarin, which are known substrates of cytochrome P-450 (CYP). However, there has not been any report to date on its possible interaction with nifedipine, an index substrate of the enzyme, CYP3A4. METHODS Nine healthy normotensive subjects participated in this randomized p...
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In traditional Chinese medicine (TCM), the human body is divided into Yin and Yang. Diseases occur when the Yin and Yang balance is disrupted. Different herbs are used to restore this balance, achieving the goal of treatment. However, inherent difficulties in designing experimental trials have left much of TCM yet to be substantiated by science. Despite that, TCM not only remains a popular form...
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For decades, warfarin has been the primary anticoagulant for the primary and secondary prevention of venous and arterial thromboembolic events. There is an extensive amount of literature that has contributed to the understanding of the complex pharmacokinetics and pharmacodynamics of warfarin, its interactions with drugs and other compounds, its antithrombotic effects, and the risks associated ...
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abstract: warfarin is the most commonly used oral anticoagulant drug in clinical practice with extreme inter and intra-individual variation in pharmacokinetic properties. na valproate, a broad spectrum anticonvulsant agent, is best known for its enzyme inhibition properties and also displacement of protein binding sites. interaction between warfarin and psychotropic drugs including valproate ar...
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ژورنال
عنوان ژورنال: Therapeutic Advances in Drug Safety
سال: 2018
ISSN: 2042-0986,2042-0994
DOI: 10.1177/2042098618796186